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Similarly, EPA and DHA can compete with arachidonic acid for the synthesis of eicosanoids.Thus, higher concentrations of EPA and DHA than arachidonic acid tip the eicosanoid balance toward less inflammatory activity [9].Within intestinal cells, free fatty acids are primarily incorporated into chylomicrons and enter the circulation via the lymphatic system [1,4].Once in the bloodstream, lipoprotein particles circulate within the body, delivering lipids to various organs for subsequent oxidation, metabolism, or storage in adipose tissue [4,5].PUFAs are distinguished from saturated and monounsaturated fatty acids by the presence of two or more double bonds between carbons within the fatty acid chain.Omega-3 fatty acids (omega-3s) have a carbon–carbon double bond located three carbons from the methyl end of the chain.

PUFAs are frequently designated by their number of carbon atoms and double bonds.

Omega-3s play important roles in the body as components of the phospholipids that form the structures of cell membranes [5].

DHA, in particular, is especially high in the retina, brain, and sperm [3,5,6].

ALA, for example, is known as C18:3n-3 because it has 18 carbons and 3 double bonds and is an n-3, or omega-3, fatty acid.

Similarly, EPA is known as C20:5n-3 and DHA as C22:6n-3.

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The eicosanoids made from omega-6s are generally more potent mediators of inflammation, vasoconstriction, and platelet aggregation than those made from omega-3s, although there are some exceptions [3,7].